Update diagnosis treatment autoimmune pancreatitis

N2 - Autoimmune pancreatitis AIP is the pancreatic manifestation of a systemic fibroinflammatory disease IgG4-related systemic disease in which affected organs demonstrate dense lymphoplasmacytic infiltration with abundant IgG4-positive cells. AB - Autoimmune pancreatitis AIP is the pancreatic manifestation of a systemic fibroinflammatory disease IgG4-related systemic disease in which affected organs demonstrate dense lymphoplasmacytic infiltration with abundant IgG4-positive cells.

Gastroenterology and Hepatology. Overview Fingerprint. Abstract Autoimmune pancreatitis AIP is the pancreatic manifestation of a systemic fibroinflammatory disease IgG4-related systemic disease in which affected organs demonstrate dense lymphoplasmacytic infiltration with abundant IgG4-positive cells. Access to Document Link to publication in Scopus. Link to the citations in Scopus. Fingerprint Dive into the research topics of 'Update on the diagnosis and treatment of autoimmune pancreatitis'.

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Start by seeing your primary care doctor if you have signs or symptoms that worry you. If your doctor suspects you may have autoimmune pancreatitis, you may be referred to a gastroenterologist or a pancreatologist.

Your time with the doctor is limited. You may feel less rushed if you make a list of questions you want to ask at your appointment. Here are some possible questions about autoimmune pancreatitis:. In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions that come up during your appointment. Your doctor is likely to ask you a number of questions. Being ready to answer them may allow more time later to cover points you want to address.

Your doctor may ask:. Autoimmune pancreatitis care at Mayo Clinic. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press.

This content does not have an English version. This content does not have an Arabic version. Diagnosis Autoimmune pancreatitis is difficult to diagnose, because its signs and symptoms are very similar to those of pancreatic cancer. Care at Mayo Clinic Our caring team of Mayo Clinic experts can help you with your autoimmune pancreatitis-related health concerns Start Here. Email address. First Name let us know your preferred name.

Last Name. Thank you for subscribing Your in-depth digestive health guide will be in your inbox shortly. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Soliman H, et al. Type 2 AIP principally affects the pancreas, with only one third having extrapancreatic magnifications, such as inflammatory bowel disease like ulcerative colitis.

Our patient, interestingly, fits into the one third of type 2 AIP cases with extrapancreatic findings as he developed persistent diarrhea. He was diagnosed with colitis, and the type of colitis was unclear via biopsy. The gastroenterologist diagnosed him as presumptive ulcerative colitis. As relapse is very common following cessation of corticosteroid use treatment, immunomodulators are needed to maintain remission for both type 1 and type 2 AIP.

Ethics Approval: Our institution does not require ethical approval for reporting individual cases or case series. Informed Consent: Written informed consent was obtained from the patient for their anonymized information to be published in this article. National Center for Biotechnology Information , U.

Published online Oct Young , MD 1, 2. Jennifer M. Mark F. Author information Article notes Copyright and License information Disclaimer. Email: ude. This article is distributed under the terms of the Creative Commons Attribution 4. This article has been cited by other articles in PMC. Abstract A middle-aged man presents with acute pancreatitis of unknown etiology and is found to have a presentation consistent with the diagnosis of type 2 autoimmune pancreatitis AIP.

Keywords: autoimmune pancreatitis, type 1, type 2, corticosteroid therapy, IgG4 antibody, IgG4-related disease, chronic pancreatitis, lymphoplasmacytic sclerosing pancreatitis. Case Report We report a case of a year-old male patient who presented with acute pancreatitis. Open in a separate window. Figure 1. Epidemiology Autoimmune pancreatitis is a group of rare heterogeneous diseases.

Table 1. Table 2. Treatment AIP is responsive to corticosteroid use in the acute setting, but relapse is common following cessation of corticosteroid use. Discussion The purpose of this case report is to review the limited knowledge that exists about AIP, particularly type 2 AIP, which is rarer than type 1 AIP, and to discuss how AIP presents clinically with methods to diagnosis this elusive disease.

References 1. Autoimmune chronic pancreatitis with IgG4-related pancreatic pseudocyst in a patient undergoing total pancreatectomy followed by autologous islet transplantation: a case report. Sugumar A, Chari S. Autoimmune pancreatitis: an update.

Expert Rev Gastroenterol Hepatol. Ketwaroo GA, Sheth S. Autoimmune pancreatitis. Gastroenterol Rep Oxf. Current concepts in the diagnosis and treatment of type 1 and type 2 autoimmune pancreatitis.

Clinicopathological features of type 2 autoimmune pancreatitis in Japan: results in a multicenter survey. Recent developments in steroid-responsive pancreatitis autoimmune pancreatitis.

Curr Opin Gastroenterol. Autoimmune pancreatitis: pathogenesis, latest developments, and clinical guidance.